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Pets

5 Best Cat Heartworm Medications

September 17, 2025 by Charlie

Top picks at a glance

  1. Advantage Multi Topical Solution for Cats, 9.1-18 lbs, 6 treatments
  2. Revolution Heartworm Topical Solution
  3. Revolution Plus Topical Solution for Cats, 5.1-15 lbs
  4. Interceptor Tablets for Dogs 51-100 lbs & Cats 12.1-25 lbs, 6 treatments
  5. NexGard Combo Topical Medication

Ready to buy now? Shop the best: 

  • Best of the Best: Advantage Multi Topical Solution for Cats
  • Best Bang for the Buck: Revolution Topical Solution for Kittens & Puppies
  • Expert-Recommended: Revolution Topical Solution for Cats
  • Easiest to Use: Interceptor Flavored Tablet for Dogs & Cats
  • Versatile Choice: NexGard COMBO Topical for Cats

Heartworm is a very dangerous medical condition caused by parasitic worms that enter the cat’s bloodstream through infected foods, fleas, or ticks. The best treatment for heartworm is prevention, and this is what prescription-grade heartworm treatments provide. Heartworm medications are often combined with flea and tick medications for a more comprehensive treatment plan, but they can also be sold as a separate product. It is important that cat owners remain vigilant when administering heartworm medication, and to look for any signs of a possible heartworm infestation in the cat’s feces. An actual case of heartworm often requires more aggressive treatment from a veterinarian.